Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations


Eosinophilic Esophagitis

In eosinophilic esophagitis, or EoE, food and/or environmental allergens enter through an impaired esophageal epithelial barrier where they stimulate a type 2 immune response, with overexpression of the cytokines IL-4, IL-5, and IL-13, as well as chemotaxins, including eotaxin-3. Inflammatory cytokines recruit eosinophils into the esophagus where they degranulate, releasing factors that activate other inflammatory cell types, including mast cells. These cells help to perpetuate inflammation, which ultimately leads to the classic endoscopic signs and clinical symptoms of EoE. Chronic inflammation results in structural changes in the esophagus, which may include edema, rings, furrows, and exudates. If left untreated, these changes may eventually progress to esophageal fibrostenotic features, such as strictures, which can cause food impaction.

Duration: 01:22
Licence: All rights reserved
Original Language: English
Published: 2/2/2023
Diseases and Conditions: Digestive Disorders
Format: 3D Animation

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Eosinophilic Esophagitis

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