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Blausen Medical
Blausen Medical

Blausen Medical

Medically accurate and informative 3D animations

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Cancer Pathways:HRR

Repairing damaged DNA is an essential capability of normal, healthy cells. Homologous recombination repair (HRR) is a DNA repair mechanism that utilizes an intact sister chromatid to correct highly toxic damage to the DNA. The HRR pathway involves the recruitment of many proteins to prep and correct a damaged strand of DNA. Using the sister chromatid as a template, the cell can replace these portions of the sequence with high fidelity. When HRR is defective, cells are less capable of fixing critical errors in the DNA sequence. In the case of tumor cells, targeting the HRR pathway results in cells that are much more sensitive to chemotherapeutic agents. The cancerous cells are unable to repair the damage caused by the therapeutics, leading to the accumulation of errors and ultimately triggering cell death.

Duration: 01:11
Licence: All rights reserved
Original Language: English
Published: 2/2/2023
Diseases and Conditions: Cancer
Format: 3D Animation

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Cancer Pathways:HRR

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