Healthcare is being transformed and to a good extent will be disrupted by digital technologies. The wisdom of people and the ability to collect, store and visualize an increasing number of data, has created new patterns for decision-making and delivery of care itself. IoT driven integrations of on-line/off-line will be creating a new connected e-health environment: more efficient and effective than today. At FrontiersX they have explored all of this, through a mix of best practices and breakthrough innovations.